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Fainting Spells: What Syncope Might Be Telling You

Fainting, or syncope, is a common symptom that can be unsettling, both for the person experiencing it and for those around them. It refers to a brief, sudden loss of consciousness, usually due to a temporary drop in blood flow to the brain. Most people recover within seconds or minutes, but the cause is not always immediately clear. In this article we will explore common causes and how these are evaluated.

In many cases, fainting is not due to a heart condition. Simple causes such as dehydration, a stomach virus, or standing up too quickly are often the reason but careful assessment is still important to rule out more serious explanations.

Common and Often Benign Causes of Syncope

Most of the fainting episodes I see in clinic turn out to be benign and situational. These include:

  • Post-micturition syncope: Fainting after urinating, especially in the middle of the night or early morning. This is often related to a sudden drop in blood pressure, especially in older adults or those taking certain medications.
  • Dehydration or illness: A viral gastroenteritis or even missing a few meals can lead to low blood pressure, particularly when standing, resulting in a brief blackout.
  • Reflex syncope: Also called vasovagal syncope, this is the most common type. It can be triggered by pain, stress, heat, prolonged standing, or even the sight of blood. People often feel light-headed, nauseous, or clammy before they faint.

These causes are generally not dangerous but still warrant a review to ensure nothing has been missed, especially if the episode was sudden or led to injury.

These types of fainting episodes often happen in predictable settings such as after getting out of bed too quickly, during a stomach bug when fluid intake has been poor, or after a trip to the bathroom in the middle of the night. People may recall feeling clammy, light-headed, or having their vision fade before briefly losing consciousness. While the experience can be distressing, the body usually recovers quickly once lying flat, allowing blood flow to return to the brain. These features help differentiate benign causes from those that are more serious and warrant deeper investigation.

However, not all fainting episodes follow this typical pattern. Some people may experience recurring episodes without a clear trigger or may notice associated symptoms like a racing heart, fatigue, or brain fog when standing features that can suggest conditions such as POTS. Others may have no warning at all before losing consciousness, raising concerns about a potential cardiac origin. Recognising these distinctions helps guide which tests are needed and whether specialist input is required.

 

Could It Be POTS?

Postural Orthostatic Tachycardia Syndrome, or POTS, is a relatively common condition, particularly among younger people, and especially in women. It can be frustrating to experience and equally challenging to diagnose. POTS is characterised by an excessive increase in heart rate when moving from lying or sitting to standing. While this may sound straightforward, the reality is far more nuanced.

People with POTS often describe a wide range of symptoms. These can include palpitations, light-headedness, and in some cases, fainting spells. But the impact goes deeper. Many also experience profound fatigue, brain fog, shakiness, nausea, or chest discomfort. Because these symptoms overlap with other conditions, individuals often undergo a series of investigations and may see several specialists before a unifying diagnosis is made.

The underlying causes of POTS are complex and not fully understood. It is thought to involve dysfunction in the autonomic nervous system, the part of the body that controls heart rate, blood pressure, and digestion. It may be triggered or worsened by infections, prolonged bed rest, or periods of physical or emotional stress.

Although POTS can significantly affect quality of life, there are effective management strategies available. These include tailored fluid and salt intake, physical reconditioning, medications to support blood pressure and heart rate control, and supportive care to manage co-existing symptoms. What is most important is that treatment is individualised, what works well for one person may not be appropriate for another. With the right approach, many people with POTS do experience meaningful improvement over time.

 

When Syncope May Point to a Heart Problem

Fainting related to a heart condition is less common but more serious. The key clues we look for include:

  • Sudden loss of consciousness without any warning signs
  • No accompanying nausea, dizziness, or sweating beforehand
  • Episodes that occur during exertion or while lying down
  • No evidence of a seizure (such as limb jerking or confusion after waking)
  • No loss of bladder or bowel control, which can suggest a neurological cause instead

While most causes of fainting are benign, we pay particular attention to episodes that suggest a cardiac origin. These are often described as sudden and without warning, no light-headedness, no nausea, no sensation of the world fading. The person simply “goes out cold.” This kind of abrupt loss of consciousness is concerning, especially if it happens during physical activity, while lying down, or in someone with known heart disease. Importantly, there are usually no signs of a neurological event, such as limb jerking, confusion afterwards, or loss of bladder or bowel control.

Cardiac syncope can be caused by rhythm disturbances (arrhythmias), such as a sudden slowing or speeding of the heart, or by structural problems like aortic stenosis or hypertrophic cardiomyopathy. These conditions can impair the heart’s ability to pump blood effectively, leading to a sudden drop in cerebral perfusion. Because these episodes can carry serious risks, we take a thorough approach to assessment including heart rhythm monitoring, echocardiography, and sometimes more advanced testing to look for electrical or structural heart abnormalities. Identifying a cardiac cause early can make a significant difference in preventing future events.

I want to delve into the particular cardiac condition we look for in assessing syncope.

 

Common Cardiac Causes of Syncope

When we suspect a cardiac cause for fainting, there are several well-recognised conditions that may be involved. These tend to fall into two categories: rhythm problems (arrhythmias) and structural abnormalities that interfere with blood flow.

Heart Block and Arrhythmias

One of the most common rhythm-related causes is a condition called heart block, where the electrical signals that control the heartbeat are delayed or completely blocked. This can lead to a very slow heart rate and result in fainting. Other arrhythmias, such as rapid heart rhythms (like ventricular tachycardia) or irregular rhythms (such as atrial fibrillation with a fast ventricular response), can also compromise blood flow to the brain and lead to loss of consciousness.

Inherited Rhythm Conditions

Some fainting episodes may be linked to inherited electrical conditions such as Brugada syndrome, long QT syndrome, or arrhythmogenic right ventricular dysplasia (ARVD). These are less common but particularly important to identify because they can affect otherwise healthy individuals, sometimes without warning. A family history of sudden cardiac death or unexplained fainting can be an important clue.

Ischaemic Heart Disease (IHD)

In people with coronary artery disease, especially those with a prior heart attack or poor heart function, scar tissue in the heart can predispose to dangerous arrhythmias. Fainting may be an early sign of this, particularly if there is underlying weakness in the heart’s pumping ability, known as a reduced ejection fraction.

Aortic Stenosis and Other Structural Issues

Aortic stenosis is a condition where the valve leading from the heart to the body becomes narrowed, restricting blood flow. In older adults, this can cause fainting during exertion, such as walking or climbing stairs. Other structural causes include hypertrophic cardiomyopathy, a thickening of the heart muscle and certain congenital heart defects that may not be diagnosed until later in life.

Each of these conditions requires a careful and often tailored approach to investigation and management. What they all share in common is the potential for sudden, unheralded fainting, a red flag that should not be ignored.

 

Neurological Causes of Syncope

While I am not a neurologist, I frequently co-manage patients with neurology colleagues when fainting spells raise questions about a potential neurological cause. There can be significant overlap in the symptoms, and I strongly believe that having two perspectives, cardiac and neurological, often leads to a clearer, more confident diagnosis.

Neurological causes of syncope are less common, but they do occur and are important not to overlook. One of the most frequent concerns is whether the event might have been a seizure. Unlike cardiac syncope, seizures are typically accompanied by additional features: limb jerking, a bitten tongue, confusion after waking (known as a postictal state), or loss of bladder or bowel control. These details, if present, can help distinguish a seizure from a fainting spell caused by blood pressure or heart rhythm changes.

Other neurological conditions that can mimic or contribute to syncope include transient ischaemic attacks (TIAs), certain types of migraines, and rare brainstem disorders. Imaging such as a CT scan or MRI of the brain is sometimes recommended when the presentation is unclear, especially if neurological signs or prolonged recovery are noted after the episode.

Ultimately, the key is a collaborative approach. When symptoms straddle the line between cardiac and neurological, involving both specialties allows us to explore all possibilities and provide patients with a well-rounded, individualised plan for investigation and care.

 

Tests We May Recommend

When evaluating a fainting episode, we take a structured approach to testing. The goal is to uncover the underlying cause while avoiding unnecessary investigations. Depending on the history, physical findings, and risk profile, the following tests may be considered:

  • Electrocardiogram (ECG): A simple test to record the heart’s electrical activity, helping us identify arrhythmias, conduction delays, or signs of past heart damage.
  • Echocardiogram: An ultrasound of the heart to assess how well it is pumping and whether any structural abnormalities might be contributing to the fainting episodes.
  • Holter monitor: A portable device worn for 24 to 48 hours that tracks the heart rhythm during normal daily activities. It is helpful when symptoms occur frequently.
  • Implantable loop recorder: When episodes are infrequent or unexplained despite initial testing, we may recommend a loop recorder. This small device is inserted just under the skin and continuously monitors the heart’s rhythm for up to several years. If fainting recurs, it allows us to capture exactly what the heart was doing at the time of the event — a valuable insight that often leads to a clear diagnosis.
  • Tilt table test: If reflex syncope or POTS is suspected, this test helps assess how your blood pressure and heart rate respond to changes in posture.
  • CT or MRI of the brain: These may be advised when neurological causes are under consideration, particularly if there were unusual features or a slow recovery after the episode.
  • Blood tests: Including checks for anaemia, electrolyte levels, thyroid function, and markers of infection or inflammation.

Not every person will need all of these tests. The choice depends on the specific features of each case. Sometimes a period of watchful waiting with symptom tracking is just as important as testing itself. The key is a thoughtful, individualised approach to make sure the right questions are being asked and answered.

 

 

Summary of Common Tests for Syncope:

  • ECG: Quick check of heart rhythm
  • Echocardiogram: Heart structure and pumping function
  • Holter monitor: 24–48 hour rhythm tracking
  • Loop recorder: Long-term heart rhythm monitoring
  • Tilt table test: Postural blood pressure and heart rate response
  • CT or MRI brain: Rule out neurological causes
  • Blood tests: Anaemia, electrolytes, thyroid function

When it comes to fainting, there is no one-size-fits-all approach. Some people need just a few simple tests, while others may benefit from longer-term monitoring. The most important step is listening to the story, that’s often where the diagnosis begins.

Conclusion

Fainting can be unsettling, especially when it happens without warning or a clear cause. While many episodes are ultimately found to be harmless linked to dehydration, reflex responses, or temporary blood pressure changes others may point to more complex underlying issues, including disturbances in heart rhythm, structural heart disease, or neurological conditions. That is why a thoughtful, structured assessment is so important.

In many cases, a detailed history and a few simple tests are enough to provide reassurance. But when uncertainty remains, longer-term monitoring or referral to multiple specialists may be needed. Conditions like POTS, inherited arrhythmias, or unexplained episodes in young people often require persistence and collaboration to reach a diagnosis. It’s not uncommon for patients to feel like they’ve been on a long journey before answers are found.

What matters most is taking each case on its own merits, looking beyond just the test results and listening carefully to how the episodes feel, what the surrounding circumstances are, and how the person is recovering. This kind of individualised care helps ensure that serious conditions are not missed, while also preventing unnecessary worry or treatment for those with more benign causes.

Whether the answer is obvious from the start or only becomes clear with time, the right investigations and a clear plan can offer both peace of mind and direction. Fainting is something that deserves attention but also perspective. Most causes are manageable, and in many cases, no treatment is needed beyond understanding what is happening and how to prevent it from recurring.

About the author
Cardiologist & Founding Editor

Peter is an interventional cardiologist and the Founding Editor of Heart Matters, a trusted resource for heart health education. With more than 20 years of clinical experience, he is dedicated to making cardiovascular care more understandable and accessible. His work bridges patient care, research, and public education, empowering individuals to take control of their heart health. Professor Barlis is internationally recognised for his contributions to cardiology, with numerous publications and speaking engagements around the world.

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other anti-anginals

When first-line therapies for angina, such as beta blockers, calcium channel blockers, and nitrates, prove inadequate or are not well-tolerated, second-line therapies may be considered.
Perhexiline is a unique medication that enhances the heart's ability to utilize fatty acids for energy, reducing its reliance on oxygen and lowering oxygen demand. This action helps improve blood flow and alleviates chest pain in some patients with refractory angina.
Nicorandil is another second-line option with a dual mechanism of action. It opens potassium channels in smooth muscle cells, causing vasodilation and enhancing coronary blood flow. Additionally, nicorandil also stimulates nitric oxide release, further dilating blood vessels and reducing heart workload.
Trimetazidine is an anti-ischemic agent that improves cardiac efficiency by enhancing glucose metabolism and shifting the heart's energy production to a more oxygen-efficient process. As second-line therapies, these medications offer alternative approaches for managing angina in individuals who do not respond adequately to first-line treatments or those experiencing side effects from other medications.

lipid lowering therapies

Lipid-lowering therapies are essential in managing coronary artery disease (CAD), a condition where the arteries supplying blood to the heart become narrowed. Among the most commonly prescribed treatments are statins, which reduce cholesterol production in the liver and significantly lower the risk of heart attacks and strokes.

Other medications may be used to target different aspects of lipid metabolism:

  • Ezetimibe helps reduce the absorption of cholesterol in the gut
  • Fibrates lower triglyceride levels
  • Niacin can help raise high-density lipoprotein (HDL) cholesterol

In recent years, a newer class of medications known as PCSK9 inhibitors—such as Repatha (evolocumab)—has become available. These drugs block a specific enzyme involved in cholesterol regulation and can dramatically lower LDL cholesterol, particularly in patients who do not achieve target levels with statins alone.

Together, these therapies provide a range of options to personalise treatment and improve cardiovascular outcomes.

Nitrates

Nitrates for Angina Relief

Nitrates are widely used to treat angina and provide quick relief from chest pain. These medications are commonly available as sublingual sprays or tablets, skin patches, and long-acting tablets.

Nitrates work by dilating blood vessels, allowing for increased blood flow and reduced vascular resistance. This reduces the heart’s workload and lowers its oxygen demand, offering prompt relief from angina symptoms.

Sublingual nitrates act quickly and are typically used at the onset of angina symptoms, while patches and long-acting tablets are used for ongoing prevention.

Common side effects include headaches, dizziness, and flushing. These often improve with continued use but should be discussed with a healthcare provider if persistent or bothersome.

calcium channel blockers

Calcium channel blockers, including amlodipine, felodipine, Cardizem (diltiazem), and verapamil, are commonly prescribed for the treatment of angina.

These medications work by inhibiting the influx of calcium into the muscle cells of the heart and blood vessels, causing them to relax. This relaxation leads to the widening of blood vessels, which improves blood flow and reduces blood pressure.

For individuals with angina, calcium channel blockers reduce the heart’s workload and oxygen demand, helping to relieve chest pain and prevent angina episodes.

While effective, they may cause side effects such as headaches, dizziness, facial flushing, and ankle swelling. These effects should be monitored and discussed with your healthcare provider if they persist.

Beta blockers

Beta blockers, such as metoprolol, propranolol, atenolol, carvedilol, and bisoprolol, play a crucial role in managing angina.

These medications work by blocking specific receptors in the heart, which slows the heart rate and reduces the strength of each contraction. This results in a lower oxygen demand by the heart and helps relieve chest pain associated with angina.

Beta blockers are highly effective in both relieving symptoms and preventing angina episodes. However, they may cause side effects in some individuals, including tiredness, worsened asthma symptoms, more vivid dreams, and erectile dysfunction in some males.

It is important to consult your healthcare provider to determine whether beta blockers are a suitable option for your angina and overall heart health.

Anti-platelet Medications

Anti-platelet medications play a crucial role in preventing blood clot formation and reducing the risk of serious cardiovascular events such as heart attacks and strokes. Commonly used agents include aspirin, clopidogrel, and ticagrelor.

 

Aspirin: This well-known medication inhibits platelet activation, reducing the likelihood that platelets will clump together and form clots. It is widely used for both primary and secondary prevention of heart attacks and strokes.

 

Clopidogrel: A potent anti-platelet agent, clopidogrel works by blocking specific receptors on platelets to prevent aggregation. It is commonly prescribed for patients with acute coronary syndrome, those undergoing stent placement, and some individuals with peripheral arterial disease.

 

Ticagrelor: Ticagrelor also inhibits platelet activation and is typically used in the treatment of acute coronary syndrome. It is often prescribed alongside aspirin to provide dual anti-platelet therapy and further reduce the risk of heart-related events.