The Pulse Newsletter Expert heart health, in plain English. Fortnightly, from our clinicians. Subscribe →
Section

Symptoms

Understanding what the body might be experiencing is an important part of heart health awareness. The Symptoms section explores some of the most common signs that people associate with heart and cardiovascular conditions — from chest discomfort and palpitations to breathlessness and fatigue. Each article is written by healthcare professionals to help readers learn more and feel better prepared for conversations with their own healthcare team.

Jump to a topic
Understanding Dizziness: A Cardiologist’s Guide
Latest in Symptoms

Understanding Dizziness: A Cardiologist’s Guide

Dizziness means something different to almost everyone who uses the word, and that description is what points to the cause. A cardiologist explains the four types, what causes each, and when your heart is involved.

All articles
Cardiac Fatigue: When Tiredness Is More Than Being Tired

Cardiac Fatigue: When Tiredness Is More Than Being Tired

Most tiredness is not your heart. But cardiac fatigue is real: heavy, persistent, and not relieved by rest. Here is how to tell the difference, and when tiredness is worth a conversation with your doctor.

Racing Heart: Causes and Patterns Explained

Racing Heart: Causes and Patterns Explained

Almost everyone has felt their heart race at some point. Most of the time it is benign and self-limiting. Sometimes it is the sign of an arrhythmia worth identifying. Here is what the different patterns mean and how they are usually approached.

Cold Hands and Feet: Causes, Circulation and What to Watch For

Cold Hands and Feet: Causes, Circulation and What to Watch For

Cold hands and feet are usually nothing to worry about. Here's how to tell when it's worth mentioning to your doctor.

Heartburn or Heart Attack? How to Tell the Difference

Heartburn or Heart Attack? How to Tell the Difference

The symptoms of heartburn and a heart attack can feel remarkably similar, but the stakes could not be more different. Here is how to tell them apart.

Breathlessness Lying Flat: What Orthopnoea Means for Your Heart

Breathlessness Lying Flat: What Orthopnoea Means for Your Heart

Needing extra pillows to sleep comfortably is not a trivial habit, it is one of cardiology's most specific symptoms of elevated cardiac filling pressure. Here is what it means.

Pain in Your Calves When Walking: Could It Be Your Arteries?

Pain in Your Calves When Walking: Could It Be Your Arteries?

A cramping pain in the calf that eases with rest can be an important signal from your cardiovascular system. Here is what peripheral arterial disease means, how it is diagnosed, and what treatment involves.

Prof. Peter Barlis
Editor's note

Understanding your condition is the single most important thing you can do after a heart diagnosis. Don't just read — ask questions, take notes, bring them to your cardiologist.

Prof. Peter Barlis · Founding Editor, Heart Matters
Morning Headaches and Your Heart: The Sleep Apnoea Connection

Morning Headaches and Your Heart: The Sleep Apnoea Connection

Waking with a dull headache that clears within an hour is a recognised symptom of sleep apnoea, a condition that is dramatically under-diagnosed and carries significant cardiovascular consequences.

Fainting Spells: What Syncope Might Be Telling You

Fainting Spells: What Syncope Might Be Telling You

Fainting can be frightening, but most causes are benign and explainable. Prof. Peter Barlis walks through the common and not-so-common causes of syncope, what the assessment involves, and when fainting deserves closer attention.

Ankle Swelling: Causes, Assessment, and When It Matters

Ankle Swelling: Causes, Assessment, and When It Matters

Ankle swelling has many causes, from long days on your feet to heart failure to medication side effects. Here is how to tell them apart and when it matters.

Deep read

Chest Pain: Understanding Symptoms, Causes and Evaluation

Chest pain has many possible causes, some cardiac, some not. Here is how doctors approach the assessment and which features matter most.

by Prof. Peter Barlis
Chest Pain: Understanding Symptoms, Causes and Evaluation
Tingling and Numbness in Your Feet: What Is Your Body Trying to Tell You?

Tingling and Numbness in Your Feet: What Is Your Body Trying to Tell You?

Many people notice tingling, numbness, or a strange burning sensation in their feet and say nothing for months. It is always worth mentioning to your doctor, here is why.

Chest Tightness and the Heart: Why This Symptom Demands Attention

Chest Tightness and the Heart: Why This Symptom Demands Attention

Chest tightness, pressure, squeezing, heaviness across the chest, is the hallmark description of angina. Here is why chest tightness always warrants assessment, and what the investigation involves.

The ACE Inhibitor Cough: A Common Side Effect with a Simple Solution

The ACE Inhibitor Cough: A Common Side Effect with a Simple Solution

A persistent dry cough that won't go away is a common side effect of ACE inhibitor medication. It may also occur during the nighttime. Here is why it happens and what to do about it.

Understanding Palpitations: A Cardiologist’s Approach

Understanding Palpitations: A Cardiologist’s Approach

Palpitations are one of the most common reasons people see a cardiologist, and one of the most reassuring. Here is what causes them and when to seek help.

Shortness of Breath and the Heart: When Breathlessness Is a Cardiac Signal

Shortness of Breath and the Heart: When Breathlessness Is a Cardiac Signal

Breathlessness is easy to explain away, but it is also one of the most important cardiac symptoms. Here is when breathlessness warrants a cardiac assessment, and what to do next.

Swollen Legs and the Heart: What the Swelling Is Telling You

Swollen Legs and the Heart: What the Swelling Is Telling You

Leg swelling beyond the ankles, into the calves and thighs, is a more significant finding than ankle oedema alone. Here is what causes leg swelling, how to tell the difference, and when to seek help.

Understanding Dizziness: A Cardiologist’s Guide

heartmatters.com 71

Dizziness means something different to almost everyone who uses the word, and that description is what points to the cause. A cardiologist explains the four types, what causes each, and when your heart is involved.

Cardiac Fatigue: When Tiredness Is More Than Being Tired

heartmatters.com 2026 03 31T213333.291
Key Points

  • Fatigue (persistent, disproportionate tiredness) is one of the most underappreciated cardiac symptoms, frequently attributed to stress, poor sleep, or ageing before a cardiac cause is considered.
  • When the heart is not pumping efficiently, the body diverts blood away from muscles and peripheral tissues to protect the brain and vital organs, producing the profound, heavy tiredness that characterises cardiac fatigue.
  • Cardiac fatigue is typically out of proportion to activity level, does not improve with rest in the way normal tiredness does, and is often accompanied by other symptoms such as breathlessness or ankle swelling.
  • Heart failure, significant valve disease, atrial fibrillation, and coronary artery disease can all present primarily as fatigue, particularly in women, older adults, and people with diabetes.
  • Fatigue that is new, progressive, or unexplained deserves investigation, not reassurance without assessment.

Fatigue is one of the great diagnostic challenges in medicine. It is almost universal, nearly everyone who sees a doctor mentions tiredness at some point. And because it is so common and so non-specific, it is often passed over quickly, attributed to lifestyle factors, and not investigated as systematically as it should be.

But cardiac fatigue has a quality that distinguishes it, and patients who have experienced it often describe it as unlike any tiredness they have felt before. It is heavy. It is persistent. It does not lift after a good night’s sleep. It limits what they can do in a way that feels disproportionate to how hard they are actually working.

It is worth saying clearly at the outset: most fatigue is not caused by the heart. Far more often the explanation is something like poor sleep, stress, a viral illness, low iron, or an underactive thyroid. But cardiac fatigue is a real and distinct thing, and understanding its causes, and the symptoms and patterns that should raise concern, is genuinely important, because fatigue is frequently the first and sometimes the only prominent symptom of significant cardiac disease.

Why the Heart Causes Fatigue

Reduced cardiac output

The heart’s primary job is to deliver oxygenated blood to every tissue in the body. When the heart is not pumping as strongly as it should, whether from a weakened heart muscle, a significant valve problem, or an irregular rhythm, the body’s tissues receive less oxygen and less fuel than they need to function normally.

The body responds with a hierarchy of protection: blood is directed preferentially to the brain and vital organs. Muscles, skin, and peripheral tissues receive less. The result is the muscular weakness, heaviness, and profound tiredness that patients with heart failure describe, the legs that feel like lead, the arms that tire carrying a bag of shopping, the effort required to do things that used to require no effort at all.

The body’s stress response

Heart failure also triggers a cascade of stress hormones and chemical signals, the body’s attempt to compensate for a struggling heart. Over time, these responses have their own side effects, including fatigue, muscle wasting, and a general sense of unwellness that goes beyond simple tiredness.

The slow onset

Cardiac fatigue typically develops gradually, so gradually that patients accommodate to it the same way they accommodate to progressive breathlessness. They stop doing things that tire them. They attribute the tiredness to getting older, to stress, to not sleeping well. By the time they present for assessment, significant cardiac compromise may already have been present for months.

One question I often ask is: “What were you able to do six months ago that feels harder now?”
These changes can be subtle and easy to dismiss as a natural part of ageing.
It is always worth a conversation with your doctor, simple tests can offer clarity and help you get that spring back in your step.

Cardiac Conditions That Present Primarily as Fatigue

Heart failure

Fatigue is one of the cardinal symptoms of heart failure, often preceding breathlessness, particularly in the early stages. The reduced pumping capacity means that even modest exertion produces a degree of tiredness that feels out of all proportion to the effort involved. Many patients describe fatigue as their most limiting symptom, even when their heart scan results show significant changes.

Atrial fibrillation

AF reduces the heart’s efficiency in several ways, the irregular rhythm is less effective than a regular one, and a fast heart rate reduces the time for the heart to fill properly between beats. Many people with AF describe fatigue and reduced exercise tolerance as their most prominent symptoms, more so than palpitations.

Significant valve disease

Aortic stenosis in particular can present with fatigue as a predominant early symptom, before breathlessness, chest pain, or dizziness become apparent. The increased effort required to pump blood through a narrowed valve can produce significant fatigue well before other symptoms develop.

Coronary artery disease

In some people, particularly women, older adults, and those with diabetes, fatigue on exertion can be the main warning sign of reduced blood flow to the heart, even without any chest pain at all. Fatigue on exertion that is out of proportion to the effort involved, in someone with cardiovascular risk factors, should always prompt a conversation with your doctor.

Bradycardia and medication effects

A significantly slow heart rate, from the heart’s own natural pacemaker slowing down, a problem with the heart’s electrical system, or medication, reduces how much blood the heart pumps with each beat, and can produce profound fatigue. Beta-blockers, which are used widely in heart medicine, can cause fatigue as a side effect, sometimes to a degree that significantly impacts quality of life. If fatigue develops after starting a new cardiac medication, the timing connection is worth discussing with the prescribing team.

Heart failure

Reduced pumping capacity leads to muscle underperfusion, heavy, persistent tiredness that does not lift with rest.

Atrial fibrillation

AF reduces the heart’s efficiency. Many people with AF experience fatigue and reduced exercise tolerance more than palpitations.

Valve disease

Aortic stenosis can present as fatigue before more classic symptoms develop, the increased workload on the heart produces energy depletion.

Coronary artery disease

Fatigue on exertion can signal reduced blood flow to the heart muscle, particularly in women, older adults, and people with diabetes where chest pain may be absent.

Bradycardia

A significantly slow heart rate reduces how much blood the heart pumps and can produce profound tiredness, sometimes worsened by cardiac medications.

Non-cardiac causes

Anaemia, thyroid disease, diabetes, sleep apnoea, depression, all require consideration alongside cardiac causes, and may coexist.

Distinguishing Cardiac Fatigue

Several features help distinguish cardiac fatigue from the more common causes of tiredness, though ultimately investigation is needed to be certain.

Cardiac fatigue tends to be related to exertion, worse with activity, somewhat better with complete rest, but never fully resolved. It is disproportionate to the level of activity involved, tasks that should be easy feel exhausting. It is progressive, getting worse over weeks and months rather than fluctuating day to day. And it is often accompanied by at least one other cardiac symptom, breathlessness, ankle swelling, palpitations, or reduced exercise tolerance, even if that symptom is mild and has been attributed to other causes.

Investigation

The investigation of unexplained or progressive fatigue should include a full blood count for anaemia, thyroid function, kidney function, a blood sugar test for diabetes, and a BNP blood test, a simple marker that indicates how hard the heart is working. A standard heart tracing (ECG) assesses rhythm and rate. A heart ultrasound (echocardiogram) provides the most comprehensive picture, how well the heart is pumping, how the valves are working, and whether there are signs of pressure building up.

If the history suggests fatigue on exertion with cardiovascular risk factors, further tests to assess blood flow to the heart may follow. A sleep study may also be arranged if sleep apnoea is suspected, it is more common than it is diagnosed, and it is a significant and treatable cause of both fatigue and cardiac risk.

Questions worth asking at your next appointment

  • Could my fatigue have a cardiac cause, and what investigations would identify or exclude this?
  • I have been more tired since starting a new medication, could this be a side effect, and is there an alternative?
  • Is my fatigue related to my heart condition, or is it likely to have another explanation?
  • Should I have a heart strain blood test and a heart ultrasound as part of the workup?
  • Could sleep apnoea be contributing, and should I have a sleep study?

Heart Matters Resource

Our Heart Health Risk Factor Checklist covers 12 cardiovascular risk categories, a useful tool to bring to any appointment investigating unexplained fatigue, to ensure the full cardiovascular picture is considered.

Download the Risk Factor Checklist →

Heart Matters Resource

When in Doubt, Get Checked Out

Fatigue that is new, progressive, disproportionate to your activity level, or accompanied by any other cardiac symptom deserves investigation, not reassurance that it is simply age or stress.

Read: When in Doubt, Get Checked Out →

Conclusion

Fatigue is easy to dismiss and easy to over-explain. “You’re working too hard.” “You’re not sleeping well.” “It’s your age.” These explanations are sometimes correct, but they should be reached after appropriate investigation, not instead of it.

Cardiac fatigue is real, specific, and measurable. It responds to treatment, sometimes dramatically. Many patients who have lived with progressive fatigue for months describe the improvement after effective heart failure therapy or AF rate control as transformative, not just feeling better, but feeling like themselves again in a way they had stopped expecting.

If your fatigue is new, progressive, or qualitatively different from normal tiredness, particularly if it limits what you can do or is accompanied by any other cardiac symptom, that is the conversation worth having with your doctor.

Related Reading

Racing Heart: Causes and Patterns Explained

racing heart
Key Points

  • A fast heart rate, known clinically as tachycardia, is defined as a resting rate above 100 beats per minute. Like a slow heart rate, it exists on a wide spectrum from entirely normal to clinically significant.
  • A racing heart felt suddenly and without obvious cause, particularly if it is regular, rapid, and accompanied by dizziness or breathlessness, is a common reason people seek cardiac assessment. An ECG recorded during the episode is one of the most useful pieces of information a clinician can have.
  • The most common causes of a persistently fast resting heart rate are dehydration, anaemia, thyroid overactivity, stimulant intake, anxiety, and fever. All are reversible once identified.
  • The main rhythm disturbances that produce a fast heart rate include atrial fibrillation, SVT, and atrial flutter. Each has a distinct pattern, and each is something a doctor can identify and discuss with you.
  • A very fast, regular, sudden-onset racing heart that does not settle with rest or simple measures is generally treated as urgent in standard clinical practice.

Almost everyone has experienced their heart racing at some point. After sprinting for a bus. During a frightening moment. After too much coffee. In those contexts it is entirely expected, entirely normal, and entirely self-limiting.

A racing heart that comes on unexpectedly, without obvious cause, and does not settle quickly, or one that is accompanied by dizziness, breathlessness, or chest discomfort, is worth understanding more carefully. The question is not just “is my heart beating fast?” but “why is it beating fast, and is this something that needs attention?”

The answer depends on several things: how fast, how regular, how sudden the onset, how long it lasts, and what else is happening at the same time.

What Is a Fast Heart Rate?

The numbers

A resting heart rate above 100 beats per minute is technically classified as tachycardia. Like most medical definitions, the threshold matters less than the context. A resting rate of 105 in someone who has just run upstairs is completely normal. A resting rate of 105 in someone sitting quietly who felt their heart suddenly accelerate is a different conversation entirely.

What your doctor will ask

When you describe a racing heart to a doctor, a few simple observations help guide the conversation more than almost anything else. Was the heartbeat regular or irregular, like a chaotic flutter? Did it come on suddenly, or build up gradually? Did it stop suddenly, or settle slowly? Were there any other symptoms at the same time, such as dizziness or breathlessness? How long did it last?

If you have a smartwatch that took an ECG or flagged an unusual rhythm at the time, that recording is genuinely useful, more useful than any description, and worth showing your doctor. A growing number of arrhythmias are now first picked up by smartwatch alerts, and clinicians take these seriously.

The most likely explanations for a fast heart rate fall into a few broad groups, all of which we cover in more detail elsewhere on Heart Matters. The non-cardiac causes listed below are by far the most common. The arrhythmia explainers cover the main rhythm disturbances in plain language, with links to dedicated guides on each.

Non-Cardiac Causes of a Fast Heart Rate

The majority of people with a persistently elevated resting heart rate have a reversible non-cardiac cause. These are important to identify because the underlying issue is usually straightforward to address once it is found.

Common Non-Cardiac Causes

Dehydration

Reduced blood volume causes the heart to beat faster to maintain output. One of the most common and easily corrected causes.

Anaemia

Reduced oxygen-carrying capacity in the blood prompts the heart to beat faster. Identified by a simple blood count.

Thyroid Overactivity

Hyperthyroidism raises the heart rate and increases arrhythmia risk. Identified by a thyroid function blood test.

Anxiety and Stress

Activation of the body’s stress response raises heart rate. Anxiety-related tachycardia is real, though cardiac causes are usually considered first.

Caffeine and Stimulants

Coffee, energy drinks, and some medications raise heart rate directly. Often underestimated as a contributor.

Fever and Infection

Every degree of temperature rise increases heart rate by around 10 beats per minute. Settles once the infection is treated.

Cardiac Arrhythmias: When the Racing Heart Is the Diagnosis

Three rhythm disturbances account for the great majority of arrhythmia-related racing heart episodes. Each has a distinctive pattern, and each is identifiable on an ECG.

SVT

Sudden onset, very regular, very fast. Starts and stops abruptly without warning. More frightening than dangerous in structurally normal hearts, and very treatable once identified.

Atrial Fibrillation

Irregular and often fast. Frequently described as a chaotic flutter rather than a steady racing. The most common sustained arrhythmia, and one of the most important to identify.

Atrial Flutter

Regular and fast, typically around 150 beats per minute. Feels like a steady rapid pounding. Similar to SVT in sensation but driven by a different mechanism in the upper chambers.

Supraventricular tachycardia (SVT)

SVT produces a sudden-onset, very regular, very fast racing heart, typically 150 to 220 beats per minute, that starts and stops abruptly without warning. It is more frightening than it is dangerous in people with structurally normal hearts, and it is one of the more treatable arrhythmias once identified. We have a dedicated article on SVT on Heart Matters.

Atrial fibrillation

AF produces an irregular, often fast racing sensation. The irregularity is one of its distinguishing features. It may feel like a chaotic fluttering rather than a regular racing. AF is the most common sustained cardiac arrhythmia and one of the most important to identify, partly because it carries an elevated stroke risk that is usually addressed with anticoagulation. Symptom management uses one of two strategies: rate control, which slows the heart down to a comfortable pace while the irregular rhythm continues, or rhythm control, which aims to restore a normal heart rhythm altogether. Which approach is chosen depends on the individual, and is a conversation with a cardiologist.

Atrial flutter

Atrial flutter typically produces a fast, regular racing heart at around 150 beats per minute, often described as a rapid but steady pounding. It can feel similar to SVT but has a different underlying mechanism. An ECG recorded during the episode is the key to telling the two apart, and the management approach is slightly different for each.

An ECG recorded during an episode of racing heart tells us more than any description afterwards. Even a smartwatch trace, shown to a doctor later, can be genuinely useful.

Prof. Peter Barlis, Interventional Cardiologist

Patterns of Presentation and How They Are Usually Approached

Most episodes of racing heart are self-limiting and not dangerous. The table below describes how different patterns are typically approached in clinical practice. It is not personalised advice. Decisions about seeking care for your own situation are best made in discussion with your doctor, or with the local emergency service if symptoms are severe.

Pattern Typical clinical approach
Racing heart with loss of consciousness or near-fainting Treated as a medical emergency, with people generally advised to call emergency services
Racing heart with chest pain or severe breathlessness Treated as a medical emergency, with people generally advised to call emergency services
Sustained fast racing heart not settling after 30 minutes Generally prompts urgent assessment. Driving oneself to hospital is usually advised against in this situation
First-ever episode of rapid irregular heart rate Same-day medical review is typical, to allow an ECG to be performed
Recurrent episodes previously investigated and confirmed benign Planned cardiology review, sometimes with a Holter monitor
Persistently fast resting rate above 100 without obvious cause Medical review within days is typical, including blood tests and an ECG
Questions Worth Raising at Your Next Appointment

  • If I have another episode, what is the best way to try to capture an ECG at the time?
  • Is my resting heart rate elevated, and has a reversible cause been considered?
  • Could my racing heart episodes be SVT, AF, or another arrhythmia?
  • Would a Holter monitor be useful in my case to try to capture the rhythm during symptoms?
  • Are there triggers I should be aware of in my own pattern, such as caffeine, alcohol, or poor sleep?

Heart Matters Resource

When in Doubt, Get Checked Out

A racing heart that is new, prolonged, irregular, or accompanied by dizziness or breathlessness is a common reason people seek assessment. An ECG recorded during the episode answers questions that no description can.

Read: When in Doubt, Get Checked Out →

Conclusion

A racing heart has many causes, most of them benign, and many of them correctable without any cardiac treatment at all. Dehydration, thyroid disease, anaemia, and anxiety all produce a fast heart rate that resolves once the underlying cause is addressed.

The pattern that more often leads to cardiac assessment is a racing heart that comes on suddenly without warning, feels rapid and regular, or is accompanied by dizziness or breathlessness, particularly if it has happened before. An ECG recorded during an episode is one of the most useful pieces of information available in working out what is going on. Most people who have their racing heart investigated come away with answers, often reassuring ones, and sometimes a diagnosis that is very treatable.

Related Reading

Cold Hands and Feet: Causes, Circulation and What to Watch For

cold hands
Key Points

  • Cold hands and feet are very common, and in most cases they reflect normal thermoregulation rather than disease. For many people the problem is transient or weather-related and signals nothing of concern.
  • When cold hands and feet come and go with the temperature, your mood, or the season, that pattern is reassuring. It is persistent, one-sided, or progressive coldness that is worth a closer look.
  • If the problem is ongoing, the causes worth considering widen to include peripheral arterial disease, Raynaud’s phenomenon, an underactive thyroid, anaemia, diabetes, and certain medications, particularly beta-blockers.
  • Peripheral arterial disease (PAD), narrowing of the arteries that supply the legs, can cause persistently cold feet, especially alongside leg pain on walking, skin colour changes, or slow-healing wounds.
  • A small number of straightforward tests, a pulse check, an ankle-brachial pressure index, and a few blood tests, can usually sort the benign from the significant. Ongoing or worsening symptoms are worth discussing with your doctor.

Cold hands and feet are one of the most commonly reported symptoms in general practice, and one of the most frequently dismissed. “Poor circulation” is the phrase most patients are given, which is vague enough to cover everything from completely normal thermoregulation to significant arterial disease.

Here is the reassuring part, and it applies to most people reading this. Cold hands and feet are very often transient. They track the weather, the season, a cold office, a drop in activity, or even stress and tiredness. When that is the pattern, the coldness is the body behaving exactly as it should, and it points to nothing wrong with the heart or the circulation at all.

For some people, though, cold extremities are the first sign of a condition that shares the same underlying process as coronary artery disease, and deserves the same attention. The practical value of this article is knowing which pattern you are dealing with, and what to do if the coldness is ongoing rather than coming and going.

Why Extremities Feel Cold

Normal thermoregulation

The body’s first priority in cool conditions is maintaining its core temperature. The nervous system does this by narrowing the blood vessels in the skin and extremities, reducing blood flow to the periphery so that warm blood keeps circulating to the brain, heart, and other vital organs. This is a normal, healthy response, and the hands and feet are the first places to feel it because they are furthest from the core.

Some people are more prone to it than others: women more than men, those with a slimmer build, and people with naturally lower blood pressure. In these individuals, cold hands and feet are a constitutional feature, not a disease. They tend to be lifelong, symmetrical, and closely tied to the temperature around them.

When it is reassuring, and when it is worth a closer look

The pattern usually tells the story. Coldness that comes and goes with the weather, eases when you warm up, affects both sides equally, and has been with you for years is reassuring. It does not need investigation.

The picture changes when cold extremities are persistent rather than intermittent, are clearly worse on one side, are getting steadily worse over months, or arrive alongside other symptoms such as leg pain on walking, skin changes, or wounds that will not heal. That is the shift from normal thermoregulation to something worth exploring, and the rest of this article walks through the possibilities.

Peripheral Arterial Disease

What it is

Peripheral arterial disease is atherosclerosis, the same process of gradual plaque build-up that affects the coronary arteries, occurring instead in the arteries that supply the legs and feet. As these narrowings progress over time, blood flow to the lower limbs becomes increasingly limited.

PAD and coronary artery disease share the same risk factors: smoking, diabetes, high blood pressure, high cholesterol, and a family history. The two conditions often coexist, which is why identifying PAD matters well beyond the legs themselves.

1 in 5
people over 65 have peripheral arterial disease, and most are unaware of it, often putting their symptoms down to ageing or general unfitness.
American Heart Association

Symptoms to be aware of

Cold feet in PAD usually come with other features that help separate it from ordinary cold sensitivity. Leg pain, cramping, or heaviness that comes on with walking and eases with rest, known as intermittent claudication, is a common feature of significant PAD. More advanced disease can cause pain in the foot or toes at night. Skin changes are also worth noting: pallor, shiny skin, loss of hair on the feet and lower legs, or wounds that are slow to heal. Any of these are worth bringing to your doctor’s attention.

Reduced or absent foot pulses in someone with cold feet, leg pain on walking, and a history of smoking or diabetes is worth investigating. It changes the cardiovascular risk conversation in an important way.

Prof. Peter Barlis, Interventional Cardiologist

Raynaud’s Phenomenon

Raynaud’s phenomenon is a different and very common condition. It is not fixed narrowing in the arteries but brief episodes of arterial spasm triggered by cold or emotional stress. The classic pattern is a sequence of colour changes in the fingers: they turn white as blood flow briefly stops, then blue as blood pools, then bright red as circulation returns. The episode is usually accompanied by numbness and tingling, and can feel uncomfortable as the fingers rewarm.

The reassuring news is that primary Raynaud’s, which occurs on its own without any underlying disease, is extremely common, more frequent in women, and in the large majority of cases entirely benign. Keeping the hands warm, avoiding sudden cold exposure, and managing stress are the main practical measures.

A less common form, secondary Raynaud’s, can occasionally be linked to connective tissue conditions. Features that might prompt your doctor to look further include a later age of onset, symptoms affecting only one hand, or associated joint pain or skin changes. If you have Raynaud’s and any of these apply, it is worth mentioning at your next appointment.

Other Causes Worth Considering

When cold hands and feet are ongoing rather than weather-related, it is worth remembering that the cause is often not the arteries at all. Several common, treatable conditions reduce peripheral warmth, and most are picked up with a simple blood test.

An underactive thyroid slows the whole metabolism and is one of the most frequent reasons for feeling cold all over, the hands and feet included, often with tiredness, weight gain, and dry skin alongside. Anaemia, where there are too few red cells to carry oxygen efficiently, can leave the extremities cold and pale and is common in women of menstruating age. Diabetes contributes in two ways, by affecting the small blood vessels and by causing nerve changes in the feet that alter how temperature is sensed. Smoking narrows blood vessels directly and is one of the most powerful and modifiable contributors of all. A naturally low body weight, low blood pressure, dehydration, and even anxiety, which diverts blood away from the skin, can all play a part.

None of these is a reason for alarm. They are listed here because they are common, they are easily tested for, and they respond well to treatment once identified.

Medications and the Heart

Sometimes the cause is not the arteries or the metabolism, but a medication. This is worth knowing, because it is common, often reversible, and easy to miss.

Beta-blockers, used widely in cardiovascular medicine for conditions including high blood pressure, heart failure, and recovery after a heart attack, can reduce blood flow to the hands and feet and make cold extremities noticeably worse. This is a known and recognised side effect, and it tends to be most noticeable in people who already have Raynaud’s or cold sensitivity. If your cold hands and feet started or became much worse after you began a beta-blocker, it is worth raising with your prescribing doctor. There are often alternatives, and your team will weigh the benefit of the medication against this side effect with you.

Reduced pumping power of the heart is a separate and more significant cause. In heart failure, the heart cannot maintain its normal output, and the body responds by diverting blood away from the skin and extremities to protect the vital organs. The result can be cold, pale, sometimes mottled hands and feet, usually as part of a broader picture that includes breathlessness, fatigue, and swelling of the ankles. Cold extremities on their own are not a sign of heart failure, but cold extremities alongside those other symptoms are worth prompt assessment.

Feature Normal / Raynaud’s Peripheral Arterial Disease
Distribution Both hands and feet symmetrically Often worse in feet; may be asymmetric
Colour changes White, blue, then red sequence (Raynaud’s) Pallor or dusky discolouration, no rewarming flush
Pain with walking Not typically Leg cramping or heaviness with exertion
Skin changes Normal skin Shiny skin, hair loss, slow wound healing
Pulses Normal Reduced or absent foot and ankle pulses

What Helps Day to Day

For the large majority of people, whose cold hands and feet are constitutional or weather-related, a few simple habits make a real difference. These measures are also the sensible first step while you arrange to have any ongoing symptoms checked.

Warm the core, not just the hands

The body warms the extremities last. A warm torso, a hat, and layered clothing do more for cold fingers and toes than gloves alone.

Keep moving

Regular activity improves circulation throughout the body. Even a short walk or wiggling the toes and fingers brings warmth back to cold extremities.

Avoid the triggers

Not smoking is the single most important step for circulation. Limiting caffeine and managing stress also help, as both can narrow small blood vessels.

When to See Your Doctor and What Tests to Expect

Cold hands and feet without any worrying features, in someone with no cardiovascular risk factors, normal skin, no leg pain on walking, and a lifelong weather-related pattern, generally do not need investigation. The day-to-day measures above are enough.

It is worth seeing your doctor when the coldness is persistent rather than intermittent, affects one side more than the other, is getting worse over time, or comes with leg pain on walking, skin changes, wounds that are slow to heal, or significant cardiovascular risk factors such as smoking, diabetes, or high blood pressure. The assessment is straightforward and usually involves no more than the following.

Your doctor will start by feeling the pulses in your feet and ankles, which gives an immediate sense of how well blood is reaching the lower limbs, and by examining the skin. An ankle-brachial pressure index, a painless test that compares the blood pressure reading at the ankle with the reading at the arm, gives a reliable picture of arterial flow to the legs and can be done at a routine appointment. A few blood tests are commonly arranged at the same time to check the thyroid, look for anaemia, and assess blood glucose. If Raynaud’s appears to be secondary rather than primary, your doctor may add an autoimmune blood screen or look at the small vessels at the base of the fingernails. Where PAD is suspected, an ultrasound scan of the leg arteries can map exactly where any narrowing lies.

Questions Worth Asking at Your Next Appointment

  • My cold hands and feet are ongoing rather than weather-related. Could they reflect reduced blood flow rather than normal cold sensitivity?
  • Should I have my pulses checked and an ankle-brachial pressure index done?
  • Could a thyroid problem, anaemia, or my blood sugar be contributing? Are those worth testing?
  • My beta-blocker seems to have made my cold hands worse, is there an alternative worth considering?
  • I have Raynaud’s, is there anything that suggests it could be related to an underlying condition?
  • I have a wound on my foot that is not healing as expected, when should I have this assessed?

Heart Matters Resource

When in Doubt, Get Checked Out

Cold feet with leg pain on walking, skin changes, or a wound that is not healing as expected is worth a conversation with your doctor. Peripheral arterial disease is treatable when it is found early, and early assessment makes a real difference.

Read: When in Doubt, Get Checked Out

Conclusion

Cold hands and feet are usually benign, the body doing exactly what it is designed to do, putting core temperature ahead of peripheral comfort. For most people the explanation is constitutional or weather-related, the symptoms come and go, and no investigation is needed.

When the coldness is ongoing, one-sided, or worsening, or comes with leg pain, skin changes, or other symptoms, the list of causes widens to include peripheral arterial disease, an underactive thyroid, anaemia, diabetes, and medication effects, all of which are readily tested for and treatable. The line between cold feet that are normal and cold feet worth discussing is usually clear from the pattern. If you are not sure which side you fall on, that uncertainty is itself a good reason to ask.

Related Reading

Breathlessness Lying Flat: What Orthopnoea Means for Your Heart

heartmatters.com 2026 04 01T210812.883
Key Points

  • Orthopnoea, breathlessness when lying flat, is a specific and clinically important cardiac symptom. It is a hallmark feature of heart failure.
  • When the heart is not pumping efficiently, lying flat redistributes fluid from the legs and abdomen into the lungs, worsening congestion and triggering breathlessness.
  • Needing extra pillows to sleep comfortably, or being unable to lie flat at all, is the classic presentation, and it is a symptom that should always be reported to a doctor.
  • Paroxysmal nocturnal dyspnoea, waking from sleep acutely breathless, needing to sit up or go to a window, is a more severe form and requires urgent assessment.
  • Orthopnoea is not a normal consequence of ageing, obesity, or being unfit. It is a symptom with a cause, and that cause is nearly always identifiable and treatable.

Most people reach for extra pillows without consciously registering what that habit represents. They started sleeping on two pillows, then three, then found that lying completely flat made them feel uncomfortable, a little breathless, uneasy. It seemed like a comfort preference, perhaps a back issue, perhaps just how they sleep.

In cardiology, the number of pillows a patient sleeps on is not a trivial question. It is one of the first things I ask when assessing heart failure. Orthopnoea, breathlessness that occurs or worsens when lying flat, is one of the most specific symptoms of elevated cardiac filling pressures and fluid accumulation in the lungs.

If you have found yourself needing more pillows to sleep comfortably, or if lying flat produces a sensation of breathlessness or unease that sitting up relieves, that symptom deserves a direct conversation with your doctor.

Why Lying Flat Causes Breathlessness

The physiology

When you stand or sit upright, gravity pools fluid in the legs and lower body. This reduces the volume of blood returning to the heart at any given moment and lessens the pressure burden on the pulmonary circulation.

When you lie flat, that fluid redistributes. Blood that was pooled in the legs now returns to the central circulation, increasing venous return, raising filling pressures in the heart, and in someone with impaired cardiac function or elevated pulmonary pressures, driving fluid into the lung tissue. The lungs become stiffer, gas exchange becomes less efficient, and breathlessness results.

In a healthy heart, this redistribution is handled without difficulty. In a heart that is already under strain, from heart failure, significant valve disease, or elevated filling pressures, lying flat can tip the balance from compensated to symptomatic.

Why the number of pillows matters

The number of pillows someone needs to sleep comfortably is a proxy for how elevated their filling pressures are. One pillow: normal. Two pillows: possibly starting to compensate. Three or more pillows, or unable to lie flat at all: filling pressures are likely significantly elevated and the heart is working hard to stay compensated.

Cardiologists even have a term for this, a patient who needs three pillows is said to have “three-pillow orthopnoea.” It sounds clinical and dry, but it captures something genuinely important: the progression from one to two to three pillows over weeks or months is a trajectory that tells a story about what is happening inside the heart.

3 pillows
Needing three or more pillows to sleep comfortably, or being unable to lie flat, is a significant clinical finding that always warrants cardiac assessment

Paroxysmal Nocturnal Dyspnoea, The More Urgent Form

Paroxysmal nocturnal dyspnoea (PND) is a more severe and alarming variant of the same mechanism. Rather than producing gradual breathlessness that prevents lying flat comfortably, PND wakes a person suddenly from sleep, often one to two hours after falling asleep, with acute, severe breathlessness.

The patient typically needs to sit up immediately, may go to an open window, and may feel a sense of panic or suffocation. The breathlessness usually improves over 15 to 30 minutes of sitting upright. It can be terrifying, and it is a symptom that requires urgent medical assessment, not the following morning’s GP appointment.

PND represents a more abrupt decompensation of the cardiac filling pressure than simple orthopnoea, and its presence usually indicates that heart failure management needs to be reviewed and intensified.

Causes

Heart failure

The most common cause of orthopnoea is heart failure, both the reduced ejection fraction variety (where the heart pumps weakly) and the preserved ejection fraction variety (where the heart pumps normally but is stiff and fills abnormally). In both, elevated left ventricular filling pressures drive the pulmonary congestion that lying flat worsens.

Significant valve disease

Mitral stenosis and severe mitral regurgitation both elevate left atrial and pulmonary pressures, the same haemodynamic mechanism. Orthopnoea in the context of known or suspected valve disease is an important symptom that may indicate the valve is now haemodynamically significant enough to require intervention.

Less common causes

Bilateral pleural effusions, fluid around both lungs, can produce positional breathlessness. Severe obesity can also produce breathlessness on lying flat through mechanical restriction rather than cardiac congestion, though cardiac causes should always be excluded first. Bilateral diaphragmatic weakness, rare but important, similarly worsens on lying supine.

Investigation

The investigation of orthopnoea begins with a BNP or NT-proBNP blood test, the cardiac stress marker that is reliably elevated when filling pressures are raised. An elevated result in someone with orthopnoea strongly supports a cardiac cause and directs the next steps.

An echocardiogram is the key imaging investigation, assessing left ventricular function, ejection fraction, valve status, and Doppler estimates of filling pressure. A chest X-ray may show pulmonary congestion or pleural effusions. The combination of these investigations usually identifies the cause efficiently.

I always ask patients with suspected heart failure how many pillows they sleep with. When that number has quietly climbed from one to three, I know things have been worsening, even if they thought they were managing fine.

— Prof. Peter Barlis, Interventional Cardiologist

Treatment

Orthopnoea is a symptom of an underlying condition, and treating the orthopnoea means treating the condition causing it. In heart failure, diuretics reduce fluid overload and relieve pulmonary congestion rapidly, many patients notice improvement in their ability to lie flat within days of optimised diuretic therapy. The broader heart failure medication regimen, the quadruple therapy of ACE inhibitors or ARBs, beta-blockers, MRAs, and SGLT2 inhibitors, addresses the underlying cardiac remodelling over longer time frames.

For valve disease, the threshold for intervention is partly determined by the presence of symptoms, orthopnoea is one of the symptoms that can tip the balance toward recommending repair or replacement.

Questions worth asking at your next appointment

  • Is my need for extra pillows a cardiac symptom, and should I have a BNP test and echocardiogram?
  • Have my filling pressures changed since my last assessment?
  • I woke from sleep acutely breathless, is this paroxysmal nocturnal dyspnoea and how urgent is it?
  • Is my diuretic dose adequate, should it be adjusted given my symptoms?
  • What change in symptoms should prompt me to contact the heart failure team or seek urgent assessment?

Heart Matters Resource

When in Doubt, Get Checked Out

If you are needing extra pillows to sleep, or have been woken from sleep acutely breathless, do not attribute this to age or habit without a medical assessment. These are cardiac symptoms until proven otherwise.

Read: When in Doubt, Get Checked Out →

Conclusion

Orthopnoea, breathlessness lying flat, is not a trivial symptom and it is not a normal part of ageing. It is a specific, clinically meaningful signal that the heart’s filling pressures are elevated and that fluid is accumulating in the lungs when gravity no longer helps to drain it away.

The extra pillow habit that develops so gradually it barely registers is worth questioning directly. How many pillows did you use a year ago? Have you stopped lying flat entirely? Have you woken from sleep breathless and frightened? These are the questions that matter, and the answers can lead to a diagnosis and a treatment that makes a real difference to how you sleep, how you feel, and how your heart is managed.

If any of this resonates, the conversation with your doctor is overdue.

More from Heart Matters

Morning Headaches and Your Heart: The Sleep Apnoea Connection

heartmatters.com 2026 03 31T221919.652
Key Points

  • Waking up with a headache, particularly a dull pressure across the forehead or behind the eyes that improves within an hour of getting up, is a recognised symptom of obstructive sleep apnoea.
  • Sleep apnoea causes repeated drops in blood oxygen overnight, raising carbon dioxide levels and dilating blood vessels in the brain, producing the characteristic morning headache.
  • Sleep apnoea is dramatically under-diagnosed and is a significant independent cardiovascular risk factor, associated with hypertension, atrial fibrillation, heart failure, and increased risk of heart attack and stroke.
  • The classic features, loud snoring, witnessed pauses in breathing, waking unrefreshed, and daytime sleepiness, are well known, but morning headache is a symptom many people don’t connect to their sleep.
  • Treatment of sleep apnoea with CPAP reduces cardiovascular risk, improves blood pressure control, and dramatically reduces the burden of atrial fibrillation in susceptible individuals.

A headache on waking is not something most people think of as a cardiac symptom. But for patients with undiagnosed obstructive sleep apnoea, it is one of the most consistent morning experiences they have, and one of the most reliably overlooked clues to a condition that significantly affects heart health.

Sleep apnoea sits at the intersection of sleep medicine and cardiology in a way that is only now being fully appreciated. It is not merely a snoring problem or a sleep quality issue. It is a condition that repeatedly stresses the cardiovascular system throughout the night, raising blood pressure, triggering arrhythmias, promoting inflammation, and increasing the long-term risk of serious cardiac events.

Recognising morning headaches, and the broader pattern of symptoms that surrounds them, as a potential signal of sleep apnoea is a genuinely useful piece of cardiovascular self-awareness.

What Is Sleep Apnoea?

The mechanism

Obstructive sleep apnoea (OSA) occurs when the muscles supporting the soft tissues of the throat relax during sleep, causing the airway to partially or completely collapse. Breathing stops, for seconds to over a minute, until the brain registers the oxygen drop and rouses the person just enough to restore airway tone. Breathing resumes with a snort or gasp, and the cycle repeats, sometimes hundreds of times per night.

The person is rarely aware of the awakenings. From the outside, the pattern is witnessed pauses in breathing followed by choking or gasping. From the inside, sleep feels unrefreshing, the morning brings heaviness and fatigue, and the day unfolds in a fog of tiredness that coffee does not fix.

Why it causes morning headaches

Each apnoea episode causes a drop in blood oxygen and a rise in carbon dioxide. Elevated CO2 is a potent dilator of blood vessels in the brain, producing increased cerebral blood flow and intracranial pressure. This is the mechanism of the morning headache: a dull, pressure-like ache, typically across the forehead or behind the eyes, that improves within an hour of being upright and awake as the overnight CO2 accumulation is cleared by normal breathing.

This pattern, headache on waking that resolves within an hour of getting up, is one of the most specific morning headache patterns for sleep apnoea. It is distinctly different from migraine, tension headache, or the headache of high blood pressure.

The Cardiovascular Consequences

Hypertension

Sleep apnoea is one of the most common causes of treatment-resistant hypertension, high blood pressure that remains elevated despite multiple medications. The repeated overnight oxygen drops and autonomic surges produce sustained elevation in sympathetic nervous system activity that carries over into daytime. Many patients with difficult-to-control blood pressure see meaningful improvement once sleep apnoea is identified and treated.

Atrial fibrillation

The relationship between sleep apnoea and AF is one of the most clinically important in cardiology. OSA is an independent risk factor for AF, and the overnight oxygen drops and autonomic surges it produces are a recognised trigger for nocturnal AF episodes. Patients with AF and untreated sleep apnoea have significantly higher AF recurrence rates after cardioversion or ablation. Treating the sleep apnoea is now considered part of comprehensive AF management.

Heart failure and coronary disease

The repeated surges in sympathetic activity, inflammation, and oxidative stress produced by untreated sleep apnoea accelerate atherosclerosis and increase the risk of heart attack and heart failure over time. Sleep apnoea is also a significant independent predictor of cardiovascular events, separate from and additive to the conventional risk factors.

~1 in 4
Adults is estimated to have some degree of obstructive sleep apnoea, with the majority undiagnosed. In people with established cardiovascular disease the proportion is considerably higher.

Recognising the Pattern

The classic presentation of sleep apnoea is well known, loud snoring, witnessed pauses in breathing, waking with a gasp or choking sensation, unrefreshing sleep, and significant daytime sleepiness. But many patients with significant OSA do not present with all of these features. The symptom pattern can be subtler, and the morning headache is one of the features that frequently goes unrecognised as part of the picture.

A useful self-assessment is the Epworth Sleepiness Scale, a simple questionnaire that scores the likelihood of dozing in eight everyday situations. A score above 10 is considered suggestive of significant daytime sleepiness and warrants further assessment. But even a normal Epworth score does not exclude sleep apnoea, some patients with significant oxygen drops overnight do not report excessive daytime sleepiness.

I ask about sleep apnoea features routinely in patients with hypertension, AF, and heart failure, because it is so common and so undertreated in these groups, and the cardiovascular impact of treating it is meaningful. A patient who tells me their partner complains about their snoring, that they wake with a headache most mornings, and that they feel exhausted regardless of how long they sleep, that patient needs a sleep study, not just more antihypertensive medication.

— Prof. Peter Barlis, Interventional Cardiologist

Diagnosis and Treatment

Sleep study

The diagnosis of sleep apnoea is made by a sleep study, either a home-based portable monitor worn overnight or a formal in-laboratory polysomnography. The test measures breathing patterns, oxygen saturation, heart rate, and sleep staging. Results are reported as the Apnoea-Hypopnoea Index (AHI), the number of breathing events per hour. Mild OSA is an AHI of 5 to 15; moderate 15 to 30; severe above 30.

CPAP, continuous positive airway pressure

CPAP is the most effective treatment for moderate to severe OSA. A mask worn during sleep delivers a gentle continuous flow of air that acts as a pneumatic splint, keeping the airway open throughout the night. Most patients notice improvement in sleep quality, morning headaches, and daytime energy within days of starting treatment.

The cardiovascular benefits of CPAP are well documented, reductions in blood pressure, improvements in AF burden, and better cardiac outcomes in patients with established heart disease. Compliance is the main challenge, patients who use CPAP consistently gain the most benefit.

Questions worth asking at your next appointment

  • Could my morning headaches be related to sleep apnoea, and should I have a sleep study?
  • My blood pressure has been difficult to control, could untreated sleep apnoea be contributing?
  • I have AF, is sleep apnoea assessment part of my management plan?
  • My partner says I snore heavily and sometimes stop breathing, what should I do about this?
  • If I start CPAP, how long before I would expect to notice a difference in my cardiovascular readings?

Heart Matters Resource

When in Doubt, Get Checked Out

If you regularly wake with a headache, feel unrefreshed regardless of sleep duration, or your partner mentions snoring or pauses in your breathing, raising this with your doctor is worth doing. The sleep study is simple, and the cardiovascular benefit of treating sleep apnoea is real.

Read: When in Doubt, Get Checked Out →

Conclusion

A morning headache that clears within an hour of getting up is an easy symptom to ignore, attribute to poor sleep, or mask with paracetamol. But in someone with snoring, unrefreshing sleep, and daytime fatigue, or in someone with difficult-to-control blood pressure or recurrent AF, it is a symptom worth taking seriously.

Sleep apnoea is common, significantly under-diagnosed, and meaningfully treatable. Its cardiovascular consequences, hypertension, AF, increased cardiac risk, are real and addressable. A sleep study is one of the lowest-barrier, highest-yield investigations in cardiovascular medicine, and for the right patient it can change the management conversation entirely.

If the pattern in this article resonates, raise it with your doctor. The investigation is simple. The benefit of getting it right is significant.

More from Heart Matters

Fainting Spells: What Syncope Might Be Telling You

heartmatters.com 68

Fainting can be frightening, but most causes are benign and explainable. Prof. Peter Barlis walks through the common and not-so-common causes of syncope, what the assessment involves, and when fainting deserves closer attention.