Welcome to Heart Matters – Empowering Heart Health
Investigations

The CT Coronary Angiogram (CTCA)

CTCA - A noninvasive scan that reveals detailed images of your heart’s arteries, what it shows, how to prepare, and why it matters.

A CT coronary angiogram, often called a CTCA, is a powerful noninvasive test that gives us a clear, detailed view of the coronary arteries, the vessels that supply blood to your heart muscle. Over time, this scan has become one of the key tools we use to assess people with suspected or early signs of coronary artery disease.

If you or a loved one have been advised to undergo a CTCA, it’s natural to have questions. What does the scan show? Is it safe? Will it give clear answers? In this article, I’ll walk you through what to expect.

 

What Is a CT Coronary Angiogram?

A CTCA uses a specialised CT scanner together with a contrast dye that is injected into a vein, usually in your arm. As the dye moves through the coronary arteries, the scanner captures detailed images of the blood vessels. This helps us assess whether there is any narrowing or plaque build up.

Unlike traditional coronary angiography, which involves inserting a tube into an artery and guiding it to the heart, CTCA is noninvasive, meaning no catheters are placed inside your body. The test is usually done as an outpatient, takes about fifteen to twenty minutes, and you can go home soon afterwards.

 

Preparing for the Scan

It is completely normal to feel a little nervous before any medical test, especially one involving your heart. The good news is that a CT coronary angiogram is a straightforward and noninvasive procedure that is usually completed in less than half an hour. However, preparation is important to ensure the images are clear and accurate so your healthcare team can make the best assessment possible.

Because your heart is constantly moving, one of the main goals is to slow the heart rate just enough to capture crisp and detailed images of the coronary arteries. A steady rhythm and a lower heart rate reduce motion artefact and allow for the clearest possible view.

Here are the usual preparation steps we ask patients to follow:

  • Avoid caffeine for at least twelve to twenty four hours before the scan. This includes coffee, tea, energy drinks, and even some types of chocolate. Caffeine can increase your heart rate and make it harder to obtain good quality images.
  • You may be prescribed a beta blocker, often taken the evening before and again on the morning of the scan. This medication helps lower your heart rate safely. Your cardiologist or clinic will provide specific instructions, including whether to take your usual medications on the day.
  • Stay calm and well rested. Anxiety or emotional stress can raise your heart rate. If you are feeling worried, let your healthcare provider know. Breathing techniques and simple relaxation exercises can help you feel more at ease.
  • Avoid strenuous activity or stimulants such as certain cold medications or supplements on the day of the test, as they may increase your heart rate or blood pressure.

Just before the scan, a nurse or doctor will insert a small cannula into a vein in your arm to administer the contrast dye. In many cases, a small spray or tablet of nitroglycerin may also be given under the tongue just before imaging begins. This helps gently widen the coronary arteries, making them easier to see.

You will lie on the scanner bed, and ECG leads will be placed on your chest to monitor your heart rhythm. The team will guide you through the process and let you know when to hold your breath briefly while the scanner captures the images.

If you have had any previous reactions to contrast dye or have a history of kidney problems, be sure to let your healthcare provider know in advance. Blood tests may be done beforehand to check your kidney function and ensure the scan is safe for you.

When the contrast dye is injected, you may feel a warm sensation that spreads from your head to your toes. This feeling typically lasts only a few seconds. Some people also describe a brief sensation similar to needing to pass urine, this is a common effect of the dye and passes quickly. Please be assured that this is entirely normal and nothing to be concerned about.

 

Preparation is important not only for the quality of the scan but to help you feel comfortable and informed throughout the process. We are here to support you every step of the way.

 

Strengths of CT Coronary Angiography

CTCA is a remarkable advancement in how we assess the heart. Some of its key benefits include:

  • It is noninvasive, no tubes or wires into your arteries apart from a cannula plaed in one of the veins usually in the forearm
  • It can be combined with a calcium score to evaluate both plaque and your overall risk
  • It provides a three-dimensional view of the arteries, offering detail not always visible on other tests
  • It is especially helpful for assessing bypass grafts in patients with previous heart surgery
  • It is excellent for ruling out significant coronary disease in people with low to intermediate risk

In many patients, a normal CTCA result offers great reassurance helping avoid unnecessary further testing or procedures.

CTCA allows us to see the coronary arteries in remarkable detail without needing to perform an invasive procedure offering clarity, comfort, and confidence.

 

Limitations and Challenges

While CTCA is an excellent test, like any tool, it has its limitations. Some factors can make the images harder to interpret:

  • Heavy calcium build-up can create artefacts that obscure the degree of narrowing
  • Stents can interfere with visualising the artery wall, making it difficult to assess whether they have re-narrowed
  • People with fast or irregular heart rhythms, such as atrial fibrillation, may not get optimal image quality

That’s why CTCA is not always the right choice for everyone. In certain situations, your doctor may recommend a different test such as a stress test, perfusion scan, or invasive coronary angiography depending on your specific condition.

 

Risks to Be Aware Of

CTCA is considered very safe, but as with any test involving contrast dye and radiation, there are a few things to keep in mind:

  • It involves radiation, but doses are now very low thanks to newer scanners
  • Allergic reactions to the contrast dye are rare but possible
  • People with reduced kidney function may be at risk of contrast-related kidney issues we check your kidney function before proceeding

Your healthcare team will assess your individual risk and make sure the test is both safe and worthwhile for you.

 

Technological Advances and the Future of CTCA

CTCA is evolving rapidly. Newer generation CT scanners provide higher quality images with faster scan times and lower radiation doses. One of the most exciting developments is photon counting CT, which delivers even clearer images, especially in patients with calcium or stents, and reduces motion artefact.

These improvements mean we can now use CTCA in even more ways, such as:

  • Planning procedures in patients with complex or calcified blockages
  • Helping interventional cardiologists choose the best stenting approach ahead of time
  • Assessing patients before valve surgery to rule out significant coronary artery disease

I see a future where CTCA replaces most diagnostic angiograms guiding decisions, planning interventions, and making invasive testing the exception rather than the rule.

A Personal Perspective

As a cardiologist, I’ve witnessed the growing value of CTCA in daily practice. It has changed the way we approach diagnosis making it possible to detect issues earlier, avoid unnecessary procedures, and tailor treatment more precisely.

The combination of safety, clarity, and accessibility makes it a test I recommend often, particularly when used thoughtfully, with sound clinical judgment.

CTCA isn’t just about seeing the arteries,  it’s about seeing the whole patient. And when used well, it allows us to personalise your care and help you make informed choices for your heart health.

 

Conclusion

CT coronary angiography has become an essential tool in the modern evaluation of coronary artery disease. Its ability to provide high-resolution, noninvasive imaging of the coronary arteries makes it a valuable first-line investigation for many patients, particularly those with low to intermediate risk profiles or unclear symptoms.

When performed with appropriate preparation and interpreted within the broader clinical context, CTCA offers important insights that can guide both diagnosis and management. It enables healthcare providers to identify or exclude significant coronary disease, plan appropriate interventions, and avoid unnecessary invasive procedures.

As technology continues to advance, the role of CTCA is expanding offering greater precision, lower radiation exposure, and broader applications in cardiovascular care. For patients, it represents a safe and accessible option that supports informed, timely, and personalised decision-making in partnership with their medical team.

About the author
Cardiologist & Founding Editor

Peter is an interventional cardiologist and the Founding Editor of Heart Matters, a trusted resource for heart health education. With more than 20 years of clinical experience, he is dedicated to making cardiovascular care more understandable and accessible. His work bridges patient care, research, and public education, empowering individuals to take control of their heart health. Professor Barlis is internationally recognised for his contributions to cardiology, with numerous publications and speaking engagements around the world.

Our Youtube Channel

Discover our Heart Matters YouTube channel, where we bring heart health to life. From explaining common conditions and symptoms to discussing the latest research, our engaging videos simplify complex topics, ensuring you have access to valuable knowledge for a healthier heart. Subscribe now and embark on a journey of education, empowerment, and inspiration.

Subscribe to our newsletter and be the first to receive valuable insights, tips, and resources on heart health.

other anti-anginals

When first-line therapies for angina, such as beta blockers, calcium channel blockers, and nitrates, prove inadequate or are not well-tolerated, second-line therapies may be considered.
Perhexiline is a unique medication that enhances the heart's ability to utilize fatty acids for energy, reducing its reliance on oxygen and lowering oxygen demand. This action helps improve blood flow and alleviates chest pain in some patients with refractory angina.
Nicorandil is another second-line option with a dual mechanism of action. It opens potassium channels in smooth muscle cells, causing vasodilation and enhancing coronary blood flow. Additionally, nicorandil also stimulates nitric oxide release, further dilating blood vessels and reducing heart workload.
Trimetazidine is an anti-ischemic agent that improves cardiac efficiency by enhancing glucose metabolism and shifting the heart's energy production to a more oxygen-efficient process. As second-line therapies, these medications offer alternative approaches for managing angina in individuals who do not respond adequately to first-line treatments or those experiencing side effects from other medications.

lipid lowering therapies

Lipid-lowering therapies are essential in managing coronary artery disease (CAD), a condition where the arteries supplying blood to the heart become narrowed. Among the most commonly prescribed treatments are statins, which reduce cholesterol production in the liver and significantly lower the risk of heart attacks and strokes.

Other medications may be used to target different aspects of lipid metabolism:

  • Ezetimibe helps reduce the absorption of cholesterol in the gut
  • Fibrates lower triglyceride levels
  • Niacin can help raise high-density lipoprotein (HDL) cholesterol

In recent years, a newer class of medications known as PCSK9 inhibitors—such as Repatha (evolocumab)—has become available. These drugs block a specific enzyme involved in cholesterol regulation and can dramatically lower LDL cholesterol, particularly in patients who do not achieve target levels with statins alone.

Together, these therapies provide a range of options to personalise treatment and improve cardiovascular outcomes.

Nitrates

Nitrates for Angina Relief

Nitrates are widely used to treat angina and provide quick relief from chest pain. These medications are commonly available as sublingual sprays or tablets, skin patches, and long-acting tablets.

Nitrates work by dilating blood vessels, allowing for increased blood flow and reduced vascular resistance. This reduces the heart’s workload and lowers its oxygen demand, offering prompt relief from angina symptoms.

Sublingual nitrates act quickly and are typically used at the onset of angina symptoms, while patches and long-acting tablets are used for ongoing prevention.

Common side effects include headaches, dizziness, and flushing. These often improve with continued use but should be discussed with a healthcare provider if persistent or bothersome.

calcium channel blockers

Calcium channel blockers, including amlodipine, felodipine, Cardizem (diltiazem), and verapamil, are commonly prescribed for the treatment of angina.

These medications work by inhibiting the influx of calcium into the muscle cells of the heart and blood vessels, causing them to relax. This relaxation leads to the widening of blood vessels, which improves blood flow and reduces blood pressure.

For individuals with angina, calcium channel blockers reduce the heart’s workload and oxygen demand, helping to relieve chest pain and prevent angina episodes.

While effective, they may cause side effects such as headaches, dizziness, facial flushing, and ankle swelling. These effects should be monitored and discussed with your healthcare provider if they persist.

Beta blockers

Beta blockers, such as metoprolol, propranolol, atenolol, carvedilol, and bisoprolol, play a crucial role in managing angina.

These medications work by blocking specific receptors in the heart, which slows the heart rate and reduces the strength of each contraction. This results in a lower oxygen demand by the heart and helps relieve chest pain associated with angina.

Beta blockers are highly effective in both relieving symptoms and preventing angina episodes. However, they may cause side effects in some individuals, including tiredness, worsened asthma symptoms, more vivid dreams, and erectile dysfunction in some males.

It is important to consult your healthcare provider to determine whether beta blockers are a suitable option for your angina and overall heart health.

Anti-platelet Medications

Anti-platelet medications play a crucial role in preventing blood clot formation and reducing the risk of serious cardiovascular events such as heart attacks and strokes. Commonly used agents include aspirin, clopidogrel, and ticagrelor.

 

Aspirin: This well-known medication inhibits platelet activation, reducing the likelihood that platelets will clump together and form clots. It is widely used for both primary and secondary prevention of heart attacks and strokes.

 

Clopidogrel: A potent anti-platelet agent, clopidogrel works by blocking specific receptors on platelets to prevent aggregation. It is commonly prescribed for patients with acute coronary syndrome, those undergoing stent placement, and some individuals with peripheral arterial disease.

 

Ticagrelor: Ticagrelor also inhibits platelet activation and is typically used in the treatment of acute coronary syndrome. It is often prescribed alongside aspirin to provide dual anti-platelet therapy and further reduce the risk of heart-related events.